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researchers proposed various image processing and deep learning methods for cancer detection, segmentation
        and visualization in three-dimensional way.
           A deep learning classification on MRI images for brain tumor detection and classification was proposed by
        Rathi  and  Palani  (2015).  They  performed  tumor  classification  using  multiple  kernel  based  probabilistic
        clustering  and  deep  learning  classifier.  In  the  segmentation  part,  median  filtering  is  used  for  image  pre-
        processing  and  multiple  kernel  based  probabilistic  clustering.  In  feature  extraction  module,  shape,  texture,
        intensity based features are extracted. Linear Discriminant Analysis (LDA) was used for selecting important
        features.  Deep  learning  classifier  is  used  in  classification  module  that  is  employed  having  two  important
        processes of training phase and testing phase. However, their research requires further improvement towards
        robust experimentation. Müller et al. (2016) proposed an automatic brain tumor segmentation with deep neural
        network. Their proposed networks are tailored to glioblastomas pictured in MR images. To segment a brain,
        their proposed method requires between 25 seconds and 3 minutes that is one order of magnitude faster than
        most state-of-art methods. Convolutional Neural Network (CNN) was used to implement a novel two-pathway
        architecture  that  learns  about  the  local  details  about  the  brain.  However,  their  research  requires  further
        investigation towards lower computational complexity.
           Damodharan and Raghavan (2015) proposed combined tissue segmentation and neural network for brain
        tumor  detection  where  pre-processing  part  consists  of  skull  stripping.  The  skull  removed  MRI  images  are
        employed  for  further  classification  of  the  brain  tissues.  In  their  research,  initial  steps  involved  in  feature
        extraction which aimed to find the neighbor blocks of the entire divided blocks, finding distance between all the
        neighbor blocks, finding the feature values of the blocks with distinct distance measures. After the feature
        extraction by Damodharan and Raghavan (2015), MRI image classification using neural network starts using
        Feed Forward Neural Network (FFNN). However, Damodharan and Raghavan (2015) could concentrate more
        in denoising issues to improve overall performance.

        3. Proposed Conceptual Framework

           Conceptual  framework  proposed  by  this  research  consists  of  two  main  parts,  i.e.  preprocessing  and
        segmentation part. Preprocessing part mainly contains noise reduction of MRI images and thresholding for
        foreground extraction. In this context, this research intends to use median filter and adaptive thresholding to
        denoise image in order to provide noise free image to the segmentation part. Another object of preprocessing is
        to  enhance  contrast  of  the  images.  In  the  preprocessing  phase,  this  research  intends  to  use  binarization
        thresholding to extract whole head section in order to eradicate the background of the MRI images that may
        interfere with further processing. After this, adaptive histogram equalization is intended to be used to enhance
        the contrast of the images. However, in the context of MRI images, overall contrast is expected to be densely
        distributed in some portion of the image, not throughout the whole image. So, adaptive histogram equalization
        initializes a window for equalizing consisting pixels. Besides, this step is expected to provide clipping the excess
        contrast and redistribute among all histograms bins (Arahusky, 2021).
           After preprocessing, maximum noise free image will be inputted in the convolutional neural network (CNN)
        where in this context this research is intended use a pretrained neural network. In the deep convolutional neural
        network that is intended to be used by this research, encoder part will be consisted of two convolutional layers.
        The first one is of stride 1 and the second one is of stride 2 followed by a max pool layer that uses nearest
        neighbor method for down-sampling which will be repeated two more times, each for lower resolutions. The
        decoder module will have other modules like encoder, i.e. max pool layer, an unpooling layer used for up-
        sampling.











        E- Proceedings of The 5th International Multi-Conference on Artificial Intelligence Technology (MCAIT 2021)   [92]
        Artificial Intelligence in the 4th Industrial Revolution
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